Publications
2024
Bone morphogenetic protein signaling: the pathway and its regulation
Akiyama, T., Raftery, LA., and Wharton, KA.
Genetics. 2024 Feb 7;226(2):iyad200.
Differential heparan sulfate-dependency of the Drosophila glypicans
Nakato, E., Kamimura, K., Knudsen, C., Masutani, S., Takemura, M., Hayashi, Y., Akiyama, T., and Nakato, H.
2023
Knudsen, C., Seuk Koh, W., Izumikawa, T., Nakato, E., Akiyama, T., Kinoshita-Toyoda, A., Haugstad, G., Yu, G., Toyoda, H., and Nakato, H.
2022
The feedback regulator Nord controls Dpp/BMP signaling via extracellular interaction with Dally in Drosophila wing
Akiyama, T., Seidel, CW and Gibson, MC.
Dev. Biol. 488:91-103.
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Impact of cilia-related genes on mitochondrial dynamics during Drosophila spermatogenesis
Bauerly, E., Akiyama, T., Yi, K and Gibson, MC.
Dev. Biol. 482:17-27.
2018
Somatic clones heterozygous for recessive disease alleles of BMPR1A exhibit unexpected phenotypes in Drosophila
Akiyama, T., User, SD and Gibson, MC.
eLife e35258.
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Regulation of neuroblast proliferation by surface glia in the Drosophila larval brain
Kanai, MI., Kim, MJ., Akiyama, T., Takemura, M., Wharton, K., O’Connor, MB., and Nakato, H.
Sci. Rep. 8(1):3730.
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Drosophila models of FOP provide mechanistic insight
Le, V., Akiyama, T., and Wharton, KA.
Bone 109:192-200.
2012
A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing
Akiyama, T., Marqués, G., and Wharton, KA.
Sci. Signal. 5: ra28.
2011
Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans
Dejima, K., Kanai, MI., Akiyama, T., Levings, DC., and Nakato, H.
J. Biol. Chem. 286: 17103-17111.
2008
Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface
Akiyama, T., Kamimura, K., Firkus, C., Takeo, S., Shimmi, O. and Nakato, H.
Dev. Biol. 313:408-419.
2005
Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog.
*Takeo, S. and *Akiyama, T., Firkus, C., Aigaki, T., Nakato, H. (2005) (*equal contribution)
Dev. Biol. 284:204-218.
2004
In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in Drosophila
Takeo, S., Fujise, M., Akiyama, T., Habuchi, H., Itano, N., Matsuo, T., Aigaki, T., Kimata, K. and Nakato, H.
J. Biol. Chem. 279:18920-18925.